| Cat.No.: | BSM-0294 |
| Product Name: | Wedelolactone |
| CAS No.: | 524-12-9 |
| Figure: |
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| Synonyms: | IKK Inhibitor II |
| Product Overview: | A natural NF-κB inhibitor |
| Description: | Wedelolactone is a natural coumestan originally isolated from plants used in herbal therapies. It inhibits NF-κB signaling at the level of IKK action, resulting in suppression of NF-κB-mediated gene expression at concentrations of 1-100 µM. Wedelolactone can also inhibit hepatitis C virus NS5B RNA-dependent RNA polymerase in vitro (IC50 = 36 µM), STAT1 dephosphorylation (50 µM), and EZH2-EED interactions (Kd = 2.8 µM). Prolonged incubation of HepG2 liver cells with wedelolactone alters lipid metabolism through increased expression of AMPK, PPARα, lipoprotein lipase, and low-density lipoprotein receptor. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 314.3 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | NF-κB |
| Molecular Formula: | C16H10O7 |
| Chemical Name: | 1,8,9-trihydroxy-3-methoxy-6H-benzofuro[3,2-c][1]benzopyran-6-one |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0201 | Recombinant Human NFKBIL2 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0294 | Wedelolactone | Inquiry |
| ◆ Antibodies | ||
| EAb-1903 | NFATC2 Polyclonal Antibody | Inquiry |
| EAb-1904 | NF-1B2 Polyclonal Antibody | Inquiry |
| EAb-1905 | NF-1A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| NF-1A | NF-1B2 | NFATC2 | NFKBIL2 |
| NFκB | NFκB1 | NFκB3 | |
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