| Cat.No.: | BSM-0292 |
| Product Name: | Gemcitabine |
| CAS No.: | 95058-81-4 |
| Figure: |
|
| Synonyms: | DDFC; LY 188011; NSC 613327 |
| Product Overview: | An anticancer nucleoside analog |
| Description: | Gemcitabine is an anticancer nucleoside analog that inhibits the growth of HL-60 promyelocytic leukemia cells with an LC50 value of 40 nM. Gemcitabine is a prodrug that is metabolized to a diphosphate and triphosphate form in cells. The triphosphate form is incorporated into DNA which induces masked chain termination and cell death. By specifically inhibiting growth arrest and DNA damage inducible protein 45 a (Gadd45a), a key mediator of active DNA demethylation, gemcitabine, at concentrations ranging from 34 to 134 nM, inhibits repair-mediated DNA demethylation in a methylation-sensitive reporter assay. Gemcitabine also has broad antiretroviral activity. |
| Appearance: | A crystalline solid |
| Molecular Weight: | 263.2 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | Gadd45a |
| Molecular Formula: | C9H11N3O4F2 |
| Chemical Name: | 2'-deoxy-2',2'-difluoro-cytidine |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0023 | Human GATAD2B Knockout Cell Line | Inquiry |
| CL-0202 | Human GABRG2 Knockout Cell Line | Inquiry |
| CL-0468 | Human GATAD2B Knockout Cell Line | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0292 | Gemcitabine | Inquiry |
| BSM-0378 | Gemcitabine-13C,15N2 (hydrochloride) | Inquiry |
| Related Gene / Proteins | |||
| GABRG2 | Gadd45a | GAR | GASC1 |
| GATA-1 | GATA-4 | GATA-6 | GATAD2A |
| GATAD2B | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
