| Cat.No.: | BSM-0264 |
| Product Name: | β-Lapachone |
| CAS No.: | 4707-32-8 |
| Figure: |
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| Synonyms: | 3,4-Dihydro-2,2-dimethyl-2H-naphtho[1,2-b]pyran-5,6-dione |
| Description: | Cell-permeable. A DNA topoisomerase I inhibitor. Unlike Camptothecin, β-lapachone does not stabilize the cleavable complex, indicating a novel mode of action. Induces apoptosis in HL-60 and human prostate cancer cells via a p53-independent mechanism and blocks the cell cycle at G0/G1. Also acts as a histone demethylase inhibitor selective to JMJ2DE (IC₅₀ =3.6 µM). |
| Appearance: | Orange solid |
| Molecular Weight: | 242.27 |
| Purity: | ≥98% by TLC |
| Storage: | -20°C |
| Targets: | DNA topoisomerase I and histone demethylase (HDM) |
| Molecular Formula: | C₁₅H₁₄O₃ |
| MDL Number: | MFCD01712233 |
| Solubility: | DMSO (100 mM) or EtOH (50 mM) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | |
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