| Cat.No.: | BSM-0261 |
| Product Name: | XL019 |
| CAS No.: | 945755-56-6 |
| Figure: |
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| Synonyms: | (S)-N-(4-(2-((4-morpholinophenyl)amino)pyrimidin-4-yl)phenyl)pyrrolidine-2-carboxamide |
| Description: | XL019 is a potent, highly selective and reversible JAK2 inhibitor (IC₅₀ = 2.2 nM). Inhibits JAK1 (IC₅₀ = 134.3 nM), JAK3 (IC50 = 214.2 nM) and TYK2 (IC₅₀ = 348.3 nM) at higher concentrations. XL019 displays significant dose-dependent pharmacodynamic and antitumor effect in a mouse xenograft model. |
| Appearance: | Light yellow to light brown solid |
| Molecular Weight: | 444.53 |
| Purity: | >98% by HPLC |
| Storage: | -20 ̊C |
| Targets: | JAK2 |
| Molecular Formula: | C₂₅H₂₈N₆O₂ |
| MDL Number: | MFCD12912450 |
| Solubility: | DMSO (~ 15 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0002 | AT9283 | Inquiry |
| ◆ Cell Lines | ||
| CL-0017 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| CL-0081 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0079 | JARID2 Polyclonal Antibody | Inquiry |
| EAb-0080 | JARID1C Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JADE1 | JAK | JAK1 | JAK2 |
| JAK3 | JAKMIP1 | JARID | JARID1 |
| JARID1A | JARID1B | JARID1C | JARID2 |
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