| Cat.No.: | BSM-0251 |
| Product Name: | UNC0646 |
| CAS No.: | 1320288-17-2 |
| Figure: |
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| Synonyms: | N-(1-cyclohexyl-4-piperidinyl)-2-[hexahydro-4-(1-methylethyl)-1H-1,4-diazepin-1-yl]-6-methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinamine |
| Description: | UNC0646 is a potent and selective inhibitor of protein lysine methyltransferases G9a and GLP activities in vitro (IC₅₀s = 6 and 15 nM, respectively) ; inhibits G9a/GLP-mediated dimethylation of histone 3 on lysine 9 in MDA-MB-231 cells (IC₅₀ = 26 nM). It is highly selective for G9a/GLP over several other protein lysine and arginine methyltransferases.UNC0646 potently inhibits G9a/GLP activity in a variety of cancer cell lines as well as in the human fetal lung IMR-90 line. |
| Appearance: | Pale yellow solid |
| Molecular Weight: | 621.9 |
| Purity: | >98% by HPLC |
| Storage: | -20 ̊C |
| Targets: | G9a |
| Molecular Formula: | C₃₆H₅₉N₇O₂ |
| MDL Number: | MFCD17215972 |
| Solubility: | DMSO (~50 mg/ml) or EtOH (~50 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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