| Cat.No.: | BSM-0250 |
| Product Name: | UNC0642 |
| CAS No.: | 1481677-78-4 |
| Figure: |
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| Synonyms: | 2-(4,4-Difluoro-1-piperidinyl)-6-methoxy-N-[1-(1-methylethyl)-4-piperidinyl]-7-[3-(1-pyrrolidinyl)propoxy]-4-quinazolinamine |
| Description: | UNC0642 is a potent, selective and cell-permeable inhibitor of G9a (EHMT2) and GLP (EHMT1) histone lysine methyltransferases. UNC0642 exhibits an in vitro IC₅₀ <15 nM with selectivity > 100-fold over 13 other HMTs and selected representatives of kinases, ion channels, 7TMs, and other epigenetic proteins. In cells, UNC0642 results in a potent reduction of H3K9me2 in MDA MB231 cells with IC₅₀ = 106 nM. |
| Appearance: | White solid |
| Molecular Weight: | 546.7 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | G9a and GLP |
| Molecular Formula: | C₂₉H₄₄F₂N₆O₂ |
| MDL Number: | MFCD17215972 |
| Solubility: | DMSO (>40 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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