| Cat.No.: | BSM-0226 |
| Product Name: | SP-2509 |
| CAS No.: | 1423715-09-6 |
| Figure: |
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| Synonyms: | 3-(4-morpholinylsulfonyl)-benzoic acid (2E)-2-[1-(5-chloro-2-hydroxyphenyl)ethylidene]hydrazide |
| Description: | SP-2509 is a reversible inhibitor of Lysine-specific demethylase (LSD1) (IC₅₀ = 13 nM). It has no effect on monoamine oxidases A and B. SP2509 attenuates the binding of LSD1 to CoREST, allowing increased methylation of H3K4 and driving increased expression of p21, p27, and CCAAT/enhancer binding protein α in cultured acute myeloid leukemia (AML) cells. |
| Appearance: | Off-white solid |
| Molecular Weight: | 437.9 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Lysine-specific demethylase (LSD1) |
| Molecular Formula: | C₁₉H₂₀ClN₃O₅S |
| MDL Number: | MFCD00002816 |
| Solubility: | DMSO (~25 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Research Kits | ||
| EKIT-0062 | Histone Demethylase LSD1 Activity/Inhibition Assay Kit | Inquiry |
| EKIT-0126 | LSD1 Inhibitor Screening Assay Kit | Inquiry |
| EKIT-0160 | LSD1 Demethylase Activity/Inhibition Fluorometric Assay Kit | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0111 | DDP-38003 dihydrochloride | Inquiry |
| BSM-0141 | GSK-LSD1 dihydrochloride | Inquiry |
| Related Gene / Proteins | |||
| LSD1 | LSD2 | LSM2 | LSM3 |
| LSM5 | LSM6 | LSP1 | |
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