| Cat.No.: | BSM-0223 |
| Product Name: | SMI-4a |
| CAS No.: | 327033-36-3 |
| Figure: |
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| Synonyms: | 5E/Z)-[[3-(Trifluoromethyl)phenyl]methylene]-2,4-thiazolidinedione |
| Description: | A selective, ATP-competitive inhibitor Pim-1 (IC₅₀ = 21 nM) and Pim-2 (IC₅₀ = 100 nM) protein kinases. Blocks mTORC1 activity via activation of AMPK. SMI-4a has been found to inhibit prostate cancer cell growth and induce G1 phase cell-cycle arrest in precursor T-cell lymphoblastic leukemia/lymphoma cell lines. |
| Appearance: | White to off-white solid |
| Molecular Weight: | 273.23 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Pim kinase |
| Molecular Formula: | C₁₁H₆F₃NO₂S |
| MDL Number: | MFCD01152003 |
| Solubility: | DMSO (>10 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0053 | PIM1 Polyclonal Antibody | Inquiry |
| EAb-0326 | PIM1 Polyclonal Antibody | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0200 | Quercetin, Dihydrate | Inquiry |
| BSM-0223 | SMI-4a | Inquiry |
| BSM-0271 | CUDC-907 | Inquiry |
| Related Gene / Proteins | |||
| PI3K | PIAS2 | PIAS4 | PIASy |
| PID | PIM | PIM1 | PIM1 |
| PIM2 | PITX2 | PiwiL2 | PIWIL4 |
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