| Cat.No.: | BSM-0220 |
| Product Name: | SIRT2 Inhibitor, B2 |
| CAS No.: | 115687-05-3 |
| Figure: |
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| Synonyms: | 5-[4-(4-Chlorobenzoyl)-1-piperazinyl]-8-nitroquinoline, CPNQ |
| Description: | Cell-permeable. A Sirtuin 2 (SIRT2) inhibitor (IC50 = 35 µM). Promotes inclusion formation in cellular models of both Huntington’s disease and Parkinson’s disease. Prevents huntingtin-mediated proteasome dysfunction and reduces α-synuclein-mediated toxicity. |
| Appearance: | Yellow solid |
| Molecular Weight: | 396.83 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | SIRT2 |
| Molecular Formula: | C₂₀H₁₇ClN₄O₃ |
| MDL Number: | MFCD02039810 |
| Solubility: | DMSO (>5 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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