| Cat.No.: | BSM-0219 |
| Product Name: | AGK2 |
| CAS No.: | 304896-28-4 |
| Figure: |
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| Synonyms: | AGK2, (2E)-2-cyano-3-[5-(2,5-dichlorophenyl)furan-2-yl]-N-(quinolin-5-yl)prop-2-enamide |
| Product Overview: | A SIRT2 inhibitor |
| Description: | AGK2 is a selective, cell-permeable inhibitor of SIRT2 (IC50 = 3.5 µM). AGK2 is >15-fold more selective for SIRT2 than SIRT1 and SIRT3. Inhibition of SIRT2 rescued α-synuclein toxicity and modified inclusion morphology in a cellular model of Parkinson’s disease. |
| Appearance: | Yellow solid |
| Molecular Weight: | 434.27 |
| Purity: | ≥95% by HPLC |
| Storage: | 4°C |
| Targets: | SIRT2 |
| Molecular Formula: | C23H13Cl2N3O2 |
| MDL Number: | MFCD01909444 |
| Solubility: | DMSO |
| Shipping Conditions: | RT |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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