| Cat.No.: | BSM-0218 |
| Product Name: | SIRT2 Inhibitor, AK-7 |
| CAS No.: | 420831-40-9 |
| Figure: |
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| Synonyms: | 3-(1-azepanylsulfonyl)-N-(3-bromphenyl)benzamide |
| Product Overview: | A brain-permeable SIRT2 inhibitor |
| Description: | A selective Sirt2 inhibitor (IC50 = 15.5 M) which does not bind Sirt1 or Sirt3. It down-regulates cholesterol biosynthesis genes in primary striatal neurons. Displays neuroprotective effects in Huntington's disease mouse models including improved motor function, extended survival and reduce brain atrophy all of which were associated with reduced aggregated mutant huntingtin. |
| Appearance: | Off-white solid |
| Molecular Weight: | 437.35 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | SIRT2 |
| Molecular Formula: | C19H21BrN2O3S |
| MDL Number: | MFCD03140195 |
| Solubility: | Dissolved in DMSO (50 mg/ml); Ethanol (8 mg/ml, warm). |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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