| Cat.No.: | BSM-0217 |
| Product Name: | EX-527 |
| CAS No.: | 49843-98-3 |
| Figure: |
|
| Synonyms: | 6-Chloro-2,3,4,8-tetrahydro-1H-carbazole-1-carboxamide (racemic) |
| Product Overview: | A SIRT1 inhibitor |
| Description: | EX 527 is a potent and selective SIRT1 class III histone deacetylase enzyme inhibitor. Increases p53 acetylation following DNA damage. Causes cell cycle arrest at G1. Inhibits differentiation and facilitates expansion of hematopoietic progenitor cells. An extremely useful tool for determining the involvement of SIRT1 in cellular physiology. Cell permeable. |
| Appearance: | Off-white solid |
| Molecular Weight: | 248.71 |
| Purity: | ≥97% by HPLC |
| Storage: | -20°C |
| Targets: | SIRT1 |
| Molecular Formula: | C13H13ClN2O |
| MDL Number: | MFCD03009471 |
| Solubility: | DMSO (20 mg/ml) |
| Shipping Conditions: | Gel pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
