PFI-3

Product Datasheets
  • Specification
  • Related Products
Cat.No.:  BSM-0194
Product Name:  PFI-3
CAS No.:  1627676-59-8
Figure: 
Synonyms:  (E)-1-(2-Hydroxyphenyl)-3-((1R,4R)-5-(pyridin-2-yl)-2,5-diazabicyclo[2.2.1]heptan-2-yl)prop-2-en-1-one
Description:  PFI-3 is a potent and selective polybromo 1 (PB1) and SMARCA4 (SWI/SNF related, Matrix associated, Actin dependent Regulator of Chromatin, subfamily A, member 4) inhibitor (Kd values are 48 and 89 nM respectively). SMARCA4, also known as BRG1 (Brahma-Related Gene1), is part of the SWI/SNF (SWItch/Sucrose Non-Fermentable) family of proteins. Loss of function of SMARCA4 and components of SWI/SNF has been linked to cancer development suggesting a tumour suppressor function for BRG1. SMARCA4 has also been shown to interact with the breast cancer gene BRCA1 (BReast CAncer 1, early onset), as well as to regulate the expression of the tumorigenic protein CD44.
Appearance:  Yellow solid
Molecular Weight:  321.37
Purity:  ≥98% by HPLC
Storage:  -20°C
Targets:  Polybromo 1 and SMARCA4
Molecular Formula:  C₁₉H₁₉N₃O₂
MDL Number:  N/A
Solubility:  DMSO (> 30 mg/ml) or EtOH (>30 mg/ml)
Shipping Conditions:  Gel Pack
Warning:  For Research Use Only! Not For Use in Humans.

Online Inquiry

For Research Use Only. Not for use in diagnostic or therapeutic procedures.
Products
Featured Products / Services

Histone Post-translational Modification Analysis

RNA Methylation Analysis

USA

Enter your email here to subscribe.

Follow us on

Easy access to products and services you need from our library via powerful searching tools

Copyright © Creative BioMart. All Rights Reserved.