| Cat.No.: | BSM-0184 |
| Product Name: | NSC-687852 |
| CAS No.: | 1009817-63-3 |
| Figure: |
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| Synonyms: | 3,5-bis[(4-nitrophenyl)methylidene]-1-prop-2-enoylpiperidin-4-one; (3E,5E)-3,5-bis[(4-nitrophenyl)methylene]-1-prop-2-enoyl-piperidin-4-one; b-AP15 |
| Description: | Cell-permeable. Abrogates the deubiquitinating activity of the 19S regulatory particle by inhibiting ubiquitin C-terminal hydrolase 5 (UCHL5) and ubiquitin-specific peptidase 14 (USP14) resulting in accumulation of polyubiquitin in cells. NSC-687852 induces tumor cell apoptosis and tumor progression in four different solid tumor models in vivo. |
| Appearance: | Pale yellow solid |
| Molecular Weight: | 419.39 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Ubiquitin C-terminal hydrolase 5 (UCHL5) |
| Molecular Formula: | C₂₂H₁₇N₃O₆ |
| MDL Number: | MFCD08705329 |
| Solubility: | DMSO (35 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0162 | LDN-57444 | Inquiry |
| BSM-0184 | NSC-687852 | Inquiry |
| BSM-0233 | TCID | Inquiry |
| ◆ Cell Lines | ||
| CL-0291 | Human UCHL1 Knockout Cell Line 11bp deletion | Inquiry |
| CL-0296 | Human UCHL3 Knockout Cell Line 11bp deletion | Inquiry |
| Related Gene / Proteins | |||
| UCHL1 | UCHL3 | UCHL5 | |
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