| Cat.No.: | BSM-0182 |
| Product Name: | NSC 146109 hydrochloride |
| CAS No.: | 59474-01-0 |
| Figure: |
|
| Synonyms: | (10-Methyl-9-anthracenyl) methyl carbamimidothioic acid ester hydrochloride; XI-011 |
| Description: | Cell-permeable. A p53 activator. It strongly activates p53 while selectively inhibiting growth of transformed cells without inducing genotoxicity. It promotes breast cancer cells to undergo apoptosis through activating p53 and inducing expression of proapoptotic genes. Recently, it has been found that activation of p53 by this small molecule is achieved through inhibition of MDMX expression. XI-011 repressed the MDMX promoter, resulting in down-regulation of MDMX mRNA level in MCF-7 cell. |
| Appearance: | Yellow solid |
| Molecular Weight: | 316.85 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | p53 |
| Molecular Formula: | C₁₇H₁₆N₂S.HCl |
| MDL Number: | MFCD08705329 |
| Solubility: | DMSO (100 mM) or EtOH (10 mM) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0182 | NSC 146109 hydrochloride | Inquiry |
| BSM-0404 | Tenovin-3 | Inquiry |
| ◆ Research Kits | ||
| EKIT-0273 | p53 Translocation Assay Kit (Cell-Based) | Inquiry |
| EKIT-0274 | p53 Transcription Factor Activity Assay Kit | Inquiry |
| EKIT-0420 | Human NFkB p50 Transcription Factor Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| p50 | p53 | ||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
