| Cat.No.: | BSM-0172 |
| Product Name: | MK-4827 |
| CAS No.: | 1038915-60-4 |
| Figure: |
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| Synonyms: | 2-[4-[(3S)-piperidin-3-yl]phenyl]indazole-7-carboxamide; Niraparib |
| Description: | MK-4827 is a potent and selective PARP-1 and PARP-2 inhibitor with IC₅₀ values of 3.8 nM and 2.1 nM, respectively. It induces synthetic lethality in preclinical tumour models with loss of BRCA and PTEN function. |
| Appearance: | Light yellow solid |
| Molecular Weight: | 320.39 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | PARP-1 and PARP-2 |
| Molecular Formula: | C₁₉H₂₀N₄O |
| MDL Number: | MFCD03453554 |
| Solubility: | DMSO (>4 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0059 | PARP Monoclonal Antibody | Inquiry |
| EAb-0061 | PARP Polyclonal Antibody | Inquiry |
| EAb-0062 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0063 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0064 | Paf1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| PABPC1L2A | PABPC5 | PABPN1 | PAD |
| PAD1 | PAD2 | PAD3 | PAD4 |
| PADI1 | PADI2 | PADI3 | PADI4 |
| PADI6 | PAF1 | PAN2 | PAPD1 |
| PAPD4 | PAPD5 | PAPD7 | PAPOLA More > |
| PAPOLB | PARD6A | PARG | PARK2 |
| PARK7 | PARP | PARP1 | PARP10 |
| PARP11 | PARP12 | PARP14 | PARP15 |
| PARP16 | PARP2 | PARP3 | PARP4 |
| PARP6 | PARP7 | PARP8 | PARP9 |
| PAX5 | PAX6 | PAX7 | PAX9 |
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