| Cat.No.: | BSM-0160 |
| Product Name: | L-α-Hydroxyglutaric Acid Disodium Salt |
| CAS No.: | 63512-50-5 |
| Figure: |
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| Synonyms: | disodium;(2S)-2-hydroxypentanedioate, Sodium (S)-2-hydroxypentanedioate, Disodium (S)-2-hydroxyglutarate, (S)-2-Hydroxypentanedioic acid disodium salt |
| Description: | L-α-Hydroxyglutaric Acid is metabolized to 2-oxoglutarate or α-ketoglutarate by L-2-hydroxyglutarate dehydrogenase. Rare defects in L-2-hydroxyglutarate dehydrogenase cause a neurometabolic disorder characterized by 2-hydroxyglutaric aciduria. High concentrations of L-α-Hydroxyglutaric Acid inhibit histone lysine demethylases, which might promote oncogenesis. 2-hydroxyglutarate can be used in the collection buffer to improve HIF-1α recovery from tumor specimens. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 192.08 |
| Purity: | ≥95% |
| Storage: | -20ºC |
| Targets: | Histone lysine demethylases |
| Molecular Formula: | C₅H₆Na₂O₅ |
| MDL Number: | MFCD05856231 |
| Solubility: | ~10 mg/ml in PBS |
| Shipping Conditions: | RT |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0007 | Recombinant Tetranucleosomes H3.3 | Inquiry |
| NUC-0008 | Recombinant Mononucleosomes H3.3 | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0009 | Histone H4 peptide (1-21), Biotin-labeled | Inquiry |
| SP-0010 | Histone H4 peptide (1-21) | Inquiry |
| SP-0012 | Histone H3 peptide (21-44), Biotin-labeled | Inquiry |
| Related Gene / Proteins | |||
| HIC1 | HIF1A | HIF1AN | HINFP |
| HIPK1 | HIPK2 | HIRA | Histone |
| Histone H1 | Histone H2A | Histone H2B | Histone H3 |
| Histone H4 | HIV-1 reverse transcriptase | ||
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