| Cat.No.: | BSM-0159 |
| Product Name: | PBIT |
| CAS No.: | 2514-30-9 |
| Figure: |
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| Synonyms: | 2-4(4-methylphenyl)-1,2-benzisothiazol-3(2H)-one |
| Description: | PBIT is a potent, cell-permeable inhibitor of Jumonji histone demethylase (JHDM). Innhibits JARID1B (also known as KDM5B or PLU1) with an IC₅₀ of about 3 μm in vitro. PBIT treatment inhibits removal of H3K4me3 by JARID1B in cells and inhibits proliferation of cells expressing higher levels of JARID1B. |
| Appearance: | White solid |
| Molecular Weight: | 241.31 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | JARID1 |
| Molecular Formula: | C14H11NOS |
| MDL Number: | MFCD05856231 |
| Solubility: | DMSO (~50 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0002 | AT9283 | Inquiry |
| ◆ Cell Lines | ||
| CL-0017 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| CL-0081 | Human JARID2 Knockout Cell Line 11bp deletion | Inquiry |
| ◆ Antibodies | ||
| EAb-0079 | JARID2 Polyclonal Antibody | Inquiry |
| EAb-0080 | JARID1C Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JADE1 | JAK | JAK1 | JAK2 |
| JAK3 | JAKMIP1 | JARID | JARID1 |
| JARID1A | JARID1B | JARID1C | JARID2 |
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