| Cat.No.: | BSM-0140 |
| Product Name: | GSK-J4 hydrochloride |
| CAS No.: | 1373423-53-0 |
| Figure: |
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| Synonyms: | Ethyl 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2--(pyridin-2- yl)pyrimidin-4-yl)amino)propanoate, monohydrochloride |
| Description: | Cell-permeable. An ethyl ester derivative of the JMJD3 selective histone demethylase inhibitor GSK-J1 (IC50> 50 μM in vitro. GSK J4 has been found to dose-dependently inhibit the production of tumor-necrosis factor-α (TNF-α), a LPS-driven cytokine involved in various fnflammatory disorders (IC50 = 9 µM). |
| Appearance: | White to off-white solid |
| Molecular Weight: | 454 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | JMJD3/UTX |
| Molecular Formula: | C24H27N5O2 • HCl |
| MDL Number: | MFCD22683852 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | UTF1 |
| UTX | |||
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