| Cat.No.: | BSM-0138 |
| Product Name: | GSK-J1 sodium salt |
| CAS No.: | 1373422-53-7 |
| Figure: |
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| Synonyms: | 3-((6-(4,5-dihydro-1H-benzo[d]azepin-3(2H)-yl)-2-(pyridin-2-yl)pyrimidin-4-yl)amino)propanoate, monosodium salt |
| Description: | A potent and selective inhibitor of the H3K27 histone demethylases JMJD3 and UTX (IC₅₀ = 60 nM for human JMJD3 in vitro). It is inactive against a panel of other JMJ family demethylases, including several variants of JMJD2 and JMJD1 and, at higher concentrations (30 μM), has no effect on more than 100 different kinases or other unrelated proteins, including other chromatin-modifying enzymes such as histone deacetylases. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 411.43 |
| Purity: | ≥95% |
| Storage: | -20°C |
| Targets: | JMJD3/UTX |
| Molecular Formula: | C₂₂H₂₂N₅O₂ ∙ Na |
| MDL Number: | MFCD22683851 |
| Solubility: | DMSO |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| EAb-0075 | JMJD2b Polyclonal Antibody | Inquiry |
| EAb-0076 | JMJD2A Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | UTF1 |
| UTX | |||
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