| Cat.No.: | BSM-0130 |
| Product Name: | EPZ015866 (GSK591) |
| CAS No.: | 1616391-87-7 |
| Figure: |
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| Synonyms: | (S)-2-(cyclobutylamino)-N-(3-(3,4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)isonicotinamide |
| Description: | EPZ015866 (GSK591) is a potent selective inhibitor of the arginine methyltransferase PRMT5/MEP50 complex thus stopping the methylation of histone H4 with IC₅₀ of 11 nM. It also maintains superior selectivity against other panels of methyl transferases inhibiting the symmetric arginine methylation of SmD3 with EC₅₀ of 56 nM. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 380.5 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | Arginine methyltransferase PRMT5/MEP50 |
| Molecular Formula: | C₂₂H₂₈N₄O₂ |
| MDL Number: | MFCD00149494 |
| Solubility: | DMSO(>40 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| BSM-0047 | SGC707 | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0048 | PRMT6 Polyclonal Antibody | Inquiry |
| EAb-0049 | PRMT7 Polyclonal Antibody | Inquiry |
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