| Cat.No.: | BSM-0126 |
| Product Name: | EPZ-5676 |
| CAS No.: | 1380288-87-8 |
| Figure: |
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| Synonyms: | (2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol |
| Description: | EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM. EPZ-5676 displays 37,000-fold selectivity over all other tested methyltransferases. It inhibits H3K79 methylation and MLL-fusion target gene expression and displays potent cell killing selective for acute leukemia lines bearing MLL translocations. |
| Appearance: | Crystalline solid |
| Molecular Weight: | 562.71 |
| Purity: | ≥98% by HPLC |
| Storage: | -20 ̊C |
| Targets: | DOT1L |
| Molecular Formula: | C30H42N8O3 |
| MDL Number: | MFCD00149494 |
| Solubility: | DMSO (~ 25 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
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