| Cat.No.: | BSM-0124 |
| Product Name: | EML-425 |
| CAS No.: | 1675821-32-5 |
| Figure: |
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| Synonyms: | 5-[(4-Hydroxy-2,6-dimethylphenyl)methylene]-1,3-bis(phenylmethyl)-2,4,6(1H,3H,5H)-pyrimidinetrione |
| Description: | EML-425 is a potent, reversible and non-competitive dual CBP and p300 inhibitor (IC₅₀ values are 1.1 and 2.9 μM, respectively). EML425 induced a marked and time-dependent reduction in the acetylation of lysine H4K5 and H3K9, a marked arrest in the G0/G1 phase and a significant increase in the hypodiploid nuclei percentage in human leukemia U937 cells. Cell-permeable. |
| Appearance: | Yellow solid |
| Molecular Weight: | 440.49 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | CBP and p300 |
| Molecular Formula: | C₂₇H₂₄N₂O₄ |
| MDL Number: | MFCD00149494 |
| Solubility: | DMSO (>40 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0038 | CTPB | Inquiry |
| BSM-0073 | Anacardic Acid | Inquiry |
| BSM-0094 | C646 | Inquiry |
| ◆ Cell Lines | ||
| CL-0055 | Human CREBBP Knockout Cell Line 1bp insertion | Inquiry |
| CL-0061 | Human EP300 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| CREB | CREB3 | crebbp | CRISP1 |
| CRISP3 | CRP | EP300 | EPC1 |
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