| Cat.No.: | BSM-0097 |
| Product Name: | Cambinol |
| CAS No.: | 14513-15-6 |
| Figure: |
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| Synonyms: | 5-[(2-hydroxy-5,8-dihydronaphthalen-1-yl)methyl]-6-phenyl-2-thioxo-2,3-dihydropyrimidin-4(1H)-one; NSC-112546 |
| Product Overview: | A SIRT1 inhibitor |
| Description: | An inhibitor of NAD-dependent deacetylase activity of human SIRT1 (IC₅₀ = 56 µM) and SIRT2(IC₅₀ = 59 µM). Acts as an antitumor agent. Treatment of BCL6-expressing Burkitt lymphoma cells with Cambinol induces apoptosis accompanied by hyperacetylation of BCL6 and p53. |
| Appearance: | Off-white solid |
| Molecular Weight: | 360.43 |
| Purity: | ≥95% by HPLC |
| Storage: | 4°C |
| Targets: | SIRT1 |
| Molecular Formula: | C₂₁H₁₆N₂O₂S |
| MDL Number: | MFCD09057543 |
| Solubility: | DMSO (10 mg/ml) |
| Shipping Conditions: | RT |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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