| Cat.No.: | BSM-0088 |
| Product Name: | BIX 01294 |
| CAS No.: | 935693-62-2 |
| Figure: |
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| Synonyms: | 2-(Hexahydro-4-methyl-1H-1,4-diazepin-1-yl)-6,7-dimethoxy-N-[1-(phenylmethyl)-4-piperidinyl]-4-quinazolinamine |
| Product Overview: | A G9a histone lysine methyltransferase (HMTase) inhibitor |
| Description: | BIX-01294 is a selective inhibitor of G9a histone methyltransferase (IC50 = 1.7 µM) as well as GLP histone methyltransferase (IC50 = 38 µM) leading to a decrease in histone H3 lysine 9 methylation (H3K9me2) in vitro. It facilitates the reactivation of pluripotency genes and induces passive demethylation, thus promoting reprogramming. BIX-01294, in combination with BAY K8644 (a calcium channel agonist), was found to improve reprogramming efficiencies of Oct4-Klf4-(OK)-infected neural progenitor cells. It induced apoptosis and decreased proliferation, mobility and invasion in human neuroblastoma cells. |
| Appearance: | Off-white solid |
| Molecular Weight: | 490.65 |
| Purity: | ≥95% by HPLC |
| Storage: | -20°C |
| Targets: | G9a/GLP; EHMT2 |
| Molecular Formula: | C28H38N6O2 |
| MDL Number: | MFCD14560563 |
| Solubility: | DMSO (10 mg/ml) or Ethanol (10 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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