| Cat.No.: | BSM-0068 |
| Product Name: | Rocilinostat (ACY-1215) |
| CAS No.: | 1316214-52-4 |
| Figure: |
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| Synonyms: | 2-(diphenylamino)-N-(7-(hydroxyamino)-7-oxoheptyl)pyrimidine-5-carboxamide ; Rocilinostat; ACT-1215 |
| Description: | ACY-1215 is a selective HDAC6 inhibitor with IC50 of 5 nM. ACY-1215 is 12-, 10-, 11 and 21-fold less active against HDAC1, HDAC2, HDAC3 and HDAC8, respectively, and minimal activity against HDAC4, 5, 7, 9, 11, SIRT1, and SIRT2. In combination with Tubastatin, it improves cognition in Alzheimer’s Disease (AD) transgenic mice. |
| Appearance: | White to off-white solid |
| Molecular Weight: | 433.5 |
| Purity: | >98% by HPLC |
| Storage: | -20 ̊C |
| Targets: | HDAC6 |
| Molecular Formula: | C24H27N5O3 |
| MDL Number: | MFCD10565969 |
| Solubility: | DMSO (>75 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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