| Cat.No.: | BSM-0066 |
| Product Name: | A-366 |
| CAS No.: | 1527503-11-2 |
| Figure: |
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| Synonyms: | 5'-Methoxy-6'-[3-(1-pyrrolidinyl)propoxy]spiro[cyclobutane-1,3'-[3H]indol]-2'-amine |
| Description: | A-366 is a potent and selective G9a/GLP histone lysine methyltransferase inhibitor (IC₅₀ = 3.3 nM). It displays >1000-fold selectivity for G9a/GLP over 21 other methyltransferases. A-366 has been shown to inhibit H3K9 methylation in prostate cancer PC3 cells with an IC₅₀ of 100 nM. |
| Appearance: | Off-white solid |
| Molecular Weight: | 329.44 |
| Purity: | ≥98% by HPLC |
| Storage: | -20°C |
| Targets: | G9a/GLP histone lysine methyltransferase |
| Molecular Formula: | C₁₉H₂₇N₃O₂ |
| MDL Number: | MFCD00010533 |
| Solubility: | DMSO (>25 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0025 | BIX01294 (hydrochloride hydrate) | Inquiry |
| BSM-0026 | UNC0224 | Inquiry |
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Cell Lines | ||
| CL-0059 | Human EHMT1 Knockout Cell Line 7bp deletion | Inquiry |
| CL-0060 | Human EHMT2 Knockout Cell Line 34bp deletion | Inquiry |
| Related Gene / Proteins | |||
| EHD2 | EHMT1 | EHMT2 | |
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