| Cat.No.: | BSM-0059 |
| Product Name: | 3-Deazaneplanocin A |
| CAS No.: | 102052-95-9 |
| Figure: |
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| Synonyms: | DZNep; NSC 617989; 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| Product Overview: | A lysine methyltransferase EZH2 (KMT63) inhibitor |
| Description: | A cell-permeable inhibitor of the histone methyltransferase EZH2. DZNep is a selective inhibitor of trimethylation of lysine 27 on histone H3 (H3K27me3) and lysine 20 on histone H4 (H4K20me3). DZNep treatment of cultured human AML cells induces increased expression of the cell-cycle regulators p21, p27, and FBXO32, leading to cell cycle arrest and apoptosis. |
| Appearance: | Off-white solid |
| Molecular Weight: | 262.26 |
| Purity: | ≥98% |
| Storage: | -20°C |
| Targets: | Lysine methyltransferase EZH2 (KMT63) |
| Molecular Formula: | C12H14N4O3 |
| Chemical Name: | 5R-(4-amino-1H-imidazo[4,5-c]pyridin-1-yl)-3-(hydroxymethyl)-3-cyclopentene-1S,2R-diol |
| MDL Number: | MFCD12545899 |
| Solubility: | DMSO (20 mg/ml) or EtOH (1 mg/ml) |
| Shipping Conditions: | Gel Pack |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0006 | GSK343 | Inquiry |
| BSM-0059 | 3-Deazaneplanocin A | Inquiry |
| BSM-0060 | 3-Deazaneplanocin A hydrochloride | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0024 | Recombinant Human EZH1 293 Cell Lysate | Inquiry |
| EL-0025 | Recombinant Human EZH2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| ezh1 | EZH2 | ||
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