| Cat.No.: | BSM-0049 |
| Product Name: | SirtAct |
| CAS No.: | 839699-72-8 |
| Figure: |
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| Synonyms: | SirtAct, Sirt1 activator 3, CAY10591, 2-Amino-N-cyclopentyl-1-(3-methoxypropyl)-1H-pyrrolo[2,3-b]quinoxaline-3-carboxamide |
| Description: | Sirt1 activator. It suppressed TNFα release from THP-1 cells and stimulated adipogenesis in 3T3L1 cells. SIRT1 stimulation by SirtAct leads to decreased tissue factor mediated thrombogenicity in mice. It inhibited NFκB activation and reduced inflammatory cytokine production in lamina propria mononuclear cells from IBD patients. It prevented and cured experimental Colitis in a mouse model. |
| Appearance: | Olive green powder. |
| Molecular Weight: | 367.4 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 3 months. |
| Targets: | SIRT1 |
| Molecular Formula: | C20H25N5O2 |
| Solubility: | Dissolved in DMSO (50 mg/ml); Ethanol (20 mg/ml, warm). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0016 | Recombinant Human SIRT1 Lysate | Inquiry |
| EL-0017 | Recombinant Human SIRT2 293 Cell Lysate | Inquiry |
| EL-0018 | Recombinant Human SIRT3 293 Cell Lysate | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0017 | Fluorogenic Sirtuin 5 Substrate | Inquiry |
| SP-0018 | Fluorogenic Sirtuin 6 Substrate | Inquiry |
| Related Gene / Proteins | |||
| Siah2 | SIK1 | SIMC1 | SIN3A |
| SIN3B | SIP1 | Sir2p | SIRT |
| SIRT1 | SIRT2 | SIRT3 | SIRT4 |
| SIRT5 | sirt6 | SIRT7 | SIX3 |
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