| Cat.No.: | BSM-0039 |
| Product Name: | Embelin |
| CAS No.: | 550-24-3 |
| Figure: |
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| Synonyms: | 2,5-Dihydroxy-3-undecyl-2,5-cyclohexadiene-1,4-dione |
| Description: | Inhibits the lysine acetyltransferase PCAF in vitro and in vivo (in vitro IC50 = 7.2 µM). Inhibits H3K9 acetylation in mouse liver tissue while leaving levels of H3K14, H4K8, and H4K12 unchanged. Also inhibits X-linked inhibitor of apoptosis (XIAP) (IC50 = 4.1 µM, competing with Smac peptide). Binds to the BIR3 domain, preventing XIAP interaction with caspase-9 and Smac. Induces apoptosis and alters gene expression profiles in breast cancer cells. Possesses anti-inflammatory and analgesic activity in vivo. Cell permeable. |
| Appearance: | Dark orange powder. |
| Molecular Weight: | 294.8 |
| Purity: | >98% (HPLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20° for up to 2 years. Store solutions at -20°C for up to 1 month. |
| Targets: | PCAF |
| Molecular Formula: | C17H26O4 |
| Solubility: | Dissolved in DMSO (30 mg/ml); or ethanol (3 mg/ml, warm). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0039 | Embelin | Inquiry |
| BSM-0108 | Curcumin, Curcuma longa (High Purity) | Inquiry |
| BSM-0133 | Garcinol | Inquiry |
| ◆ Antibodies | ||
| EAb-0060 | PCAF Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0106 | Recombinant Human PCNA Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| PCAF | PCBP2 | PCBP3 | PCBP4 |
| PCGF2 | PCGF6 | PCL2 | PCNA |
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