| Cat.No.: | BSM-0035 |
| Product Name: | Arecoline hydrobromide |
| CAS No.: | 300-08-3 |
| Figure: |
|
| Synonyms: | Arecoline hydrobromide, 1,2,5,6-tetrahydro-1-methyl-3-pyridinecarboxylic acid, methyl ester, hydrobromide |
| Description: | Tyrosine 407 phosphorylation activates mitochondrial acetyl-CoA acetyltransferase 1 (ACAT1) by stabilizing its tetramer. This is believed to be the mechanisms by which ACAT1 is "hijacked" and contributes to the Warburg effect in cancer. Arecoline is a covalent inhibitor of ACAT1 which binds to and disrupts only ACAT1 tetramers (IC50 = 11.1 µM). ACAT2 and DLAT are not inhibited. Treatment of xenograft nude mice with Arecoline resulted in a dose-dependent reduction in tumor mass. Agonist at muscarinic acetylcholine receptors M1-M5 (EC50 in the range of 7-410 nM). May be effective in dementia. |
| Appearance: | White crystalline powder. |
| Molecular Weight: | 236.1 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at room temperature for up to 2 years. Do not store solutions for longer than one day. |
| Targets: | ACAT1 |
| Molecular Formula: | C8H13NO2 • HBr |
| Solubility: | Dissolved in water (50 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0035 | Arecoline hydrobromide | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0045 | Recombinant Human ACTL6A 293 Cell Lysate | Inquiry |
| EL-0046 | Recombinant Human ACTL6A 293 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0193 | Human ACRBP Knockout Cell Line | Inquiry |
| ◆ Antibodies | ||
| EAb-0201 | BAF53B Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| ACAT1 | ACRBP | ACTL6 | ACTR8 |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
