| Cat.No.: | BSM-0034 |
| Product Name: | 6-Thioguanine |
| CAS No.: | 154-42-7 |
| Figure: |
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| Synonyms: | 6-Thioguanine, 2-Amino-6-mercaptopuring; 6-TG; NSC 752; NSC 76504 |
| Description: | After incorporation into DNA, it disrupts cytosine methylation by DNA methyltransferases in vitro and acts as a DNA demethylating agent in vivo. It reactivates epigenetically silenced genes in acute lymphoblastic leukemia cells by facilitating proteasome-mediated degradation of DNA methyltransferase (DNMT1). Incorporates into DNA and induces double-strand breaks which destabilize DNA structure resulting in cytotoxicity. Selectively kills BRCA2-defective tumors and overcomes PARP inhibitor resistance in xenograft model. Anti-cancer and immunosuppressive activity. |
| Appearance: | Pale yellow powder. |
| Molecular Weight: | 167.2 |
| Purity: | >96% (HPLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at room temperature for up to 2 years. Store solutions at -20°C for up to 1 month. |
| Molecular Formula: | C5H5N5S |
| Solubility: | Dissolved in DMF (1.5 mg/ml, warm). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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