| Cat.No.: | BSM-0033 |
| Product Name: | 5-Azacytidine |
| CAS No.: | 320-67-2 |
| Figure: |
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| Synonyms: | 4-Amino-1-β-D-ribofuranosyl-1,3,5-triazin-2(1H)-one Ladakamycin; U-18496; NSC-102816; 5-AzaC |
| Description: | Specific and potent inhibitor of DNA methyltransferase, DNMT1. Acts as a suicide substrate for methyltransferases after incorporation into DNA. Induces apoptosis in HCT-116 colon cancer cells which is mediated by p53 and its downstream effectors p21 (WAF1) and GADD45. Increases stem cell reprogramming efficiency. Induces cardiac differentiation of human umbilical cord-derived MSCs. Reverses drug resistance in bladder cancer cells. Antileukemic agent. Cell permeable. |
| Appearance: | White powder. |
| Molecular Weight: | 244.2 |
| Purity: | >98% (TLC); NMR (Conforms) |
| Storage: | Store desiccated as supplied at -20°C for up to 2 years. Store solutions at -20°C for up to 1 month. |
| Molecular Formula: | C8H12N4O5 |
| Solubility: | Dissolved in DMSO (25 mg/ml); Water (12 mg/ml). |
| Warning: | For Research Use Only! Not For Use in Humans. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0008 | Vinorelbine Tartrate | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0027 | Recombinant Human DNMT3A 293 Cell Lysate | Inquiry |
| EL-0028 | Recombinant Human DNMT3B 293 Cell Lysate | Inquiry |
| EL-0029 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| EL-0030 | Recombinant Human DNMT3L 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| DNA alkyltransferase | DNAJC2 | DNAS1L1 | DNASE1L3 |
| DNMT | DNMT1 | DNMT2 | DNMT3A |
| DNMT3B | DNMT3L | DNMT4 | |
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