| Cat.No.: | EKIT-0573 |
| Product Name: | PAD2 Inhibitor Screening Assay Kit (AMC) |
| Size: | 96 reactions |
| Product Overview: | A convenient method for screening human PAD2 inhibitors |
| Description: | PAD2 Inhibitor Screening Assay Kit (AMC) provides a convenient method for screening human PAD2 inhibitors. |
| Background: | Protein arginine deiminase 2 (PAD2) is a guanidino-modifying enzyme that catalyzes the conversion of specific arginine residues to citrulline in a calcium-dependent manner. This enzyme has been implicated in several diseases, including rheumatoid arthritis (RA), retinal degeneration, and certain cancers. PAD2 has been shown to modify vimentin, fibrinogen, and β/γ-actin. Extracellular levels of PAD2 are increased in the lungs of smokers, providing a link between smoking as a risk factor for RA and anti-citrullinated protein antibodies among RA patients. |
| Features & Benefits: | Screen for inhibitors of PAD2; Assay 45 samples in duplicate; Plate-based fluorometric measurement (ex 355-365 nm, em 445-455 nm); Low background, high sensitivity |
| Storage: | -80°C |
| Warning: | For research use only, not for diagnostic use. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0059 | PARP Monoclonal Antibody | Inquiry |
| EAb-0061 | PARP Polyclonal Antibody | Inquiry |
| EAb-0062 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0063 | PARP (Cleaved) Polyclonal Antibody | Inquiry |
| EAb-0064 | Paf1 Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| PABPC1L2A | PABPC5 | PABPN1 | PAD |
| PAD1 | PAD2 | PAD3 | PAD4 |
| PADI1 | PADI2 | PADI3 | PADI4 |
| PADI6 | PAF1 | PAN2 | PAPD1 |
| PAPD4 | PAPD5 | PAPD7 | PAPOLA More > |
| PAPOLB | PARD6A | PARG | PARK2 |
| PARK7 | PARP | PARP1 | PARP10 |
| PARP11 | PARP12 | PARP14 | PARP15 |
| PARP16 | PARP2 | PARP3 | PARP4 |
| PARP6 | PARP7 | PARP8 | PARP9 |
| PAX5 | PAX6 | PAX7 | PAX9 |
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