| Cat.No.: | EKIT-0279 |
| Product Name: | TAF1 bromodomains 1 and 2 TR-FRET Assay Kit |
| Description: | TAF1, a component of transcription factor IID, interacts with transcriptional activators to promote transcription. Recognition of acetylated lysine residues via its two bromodomains directs TAF1 binding to the core promoter sequences at the transcription start site. Through its interactions with the androgen receptor, TAF1 has been implicated in castration-resistant prostate cancer. TAF1 also has been shown to regulate expression of the pro-apoptotic protein p27kip1, potentially linking TAF1 expression to the cellular response to genotoxic stress. The TAF1 bromodomains 1 and 2 TR-FRET Assay Kit is a homogeneous TR-FRET assay method amenable to rapid characterization of inhibitors of bromodomain/acetylated peptide interaction in a high throughput format. This screening assay kit is robust, displaying a Z >0.6. |
| Kit Components: | TAF1 bromodomains 1 and 2 Europium Chelate: 1 vial/420 wells; 5 vials/ 420 wells; 5 vials/ 2,100 wells; -80°CTAF1 bromodomains 1 and 2 Ligand/APC Acceptor Mixture: 1 vial/420 wells; 5 vials/ 420 wells; 5 vials/ 2,100 wells; -80°C TR-FRET Assay Buffer (10X): 1 vial/2 ml; 1 vial/10 ml; 5 vials/10 ml; -20°C TR-FRET Assay Buffer Additive: 1 vial/200 mg; 1 vial/1 g; 5 vials/1 g; -20°C H4 Positive Control: 1 vial/2.5 nmol; 5 vials/2.5 nmol; 5 vials/12.5 nmol; -80°C 384-Well Solid Plate (low volume; black): 1 plate; 5 plates; 25 plates; Room temperature Foil Plate Covers: 1 cover; 5 covers; 25 covers; Room temperature |
| Warning: | For research use only, not for diagnostic use. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0017 | TAF1 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0056 | Recombinant Human TAL1 293 Cell Lysate | Inquiry |
| EL-0108 | Recombinant Human TAF7 293 Cell Lysate | Inquiry |
| EL-0178 | Recombinant Human TADA1 Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0121 | Human TAP2 Knockout Cell Line | Inquiry |
| Related Gene / Proteins | |||
| TADA1 | TADA1L | TADA2A | TADA2B |
| TADA3 | TAE1 | TAF-I | taf1 |
| TAF1L | TAF6L | TAF7 | TAF7L |
| TAL1 | TAP2 | TAZ | |
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