| Cat.No.: | PE-3840 |
| Product Name: | KAT9 (ELP3)-GST fusion |
| Description: | KAT9 (ELP3)-GST fusion protein. Recombinant full-length human KAT9 (ELP3) was expressed by baculovirus in Sf9 insect cells using an N-Terminal Glutathione-S-Transferase fusion protein. |
| Background: | KAT9 (also known as ELP3) is the catalytic subunit of the histone acetyltransferase (HAT) elongator complex, which contributes to transcript elongation and also regulates the maturation of projection neurons. The knockdown of KAT9 by antisense morpholinos in zebrafish embryos resulted in dose-dependent shortening and abnormal branching of motor neurons with no concomitant morphologic abnormalities. KAT9 knockdown also impairs paternal DNA demethylation as indicated by reporter binding, immunostaining, and bisulfite sequencing. |
| Applications: | Suitable for use in Western Blot. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid (sterile filtered) |
| Molecular Weight: | ~86kDa |
| Purity: | The purity was determined to be >75% by densitometry. |
| Species: | Human |
| Formulation: | 50mM Tris-HCl, pH 7.5, 150mM NaCl, 10mM glutathione, 0.1mM EDTA, 0.25mM DTT, 0.1mM PMSF, 25% glycerol. |
| Alternative Names: | KAT9, ELP3, FLJ10422, Elongator complex protein 3, hELP3, EC 2.3.1.48 |
| Tag: | GST |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0073 | Anacardic Acid | Inquiry |
| ◆ Antibodies | ||
| EAb-0073 | KAT8 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0083 | Human KAT2A Knockout Cell Line 1bp insertion | Inquiry |
| CL-0085 | Human KAT2B Knockout Cell Line 31bp deletion | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0159 | Recombinant Human MYST2 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| ELAVL3 | ELE1 | Elk-1 | ELP2 |
| ELP3 | ELP4 | Kaiso | KANSL2 |
| KAP1 | KAT13A | KAT13D | KAT2A |
| KAT2B | KAT4 | KAT5 | KAT6A |
| KAT6B | KAT7 | KAT8 | KAT9 |
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