| Cat.No.: | PE-3825 |
| Product Name: | HDAC11 (human), (recombinant) (His-tag) |
| Description: | HDAC11 from human cDNA, transcript variant 1 (identical to GenBank accession NM_024827) is fused at the N-terminus to a His-tag. Produced in a baculovirus expression system. |
| Background: | While the other ten human HDACs fall into either the class I (HDACs 1-3, 8) or class II (HDACs 4-7, 9, 10) homology groups, HDAC11 is the sole human representative in class IV.In contrast to the ubiquitous expression of most human HDACs, high level expression of HDAC11 is limited, in normal human tissues, to brain, heart, skeletal muscle, kidney and testis, suggesting possible tissue-specific or developmental functions. HDAC11 appears to play a role in neural cell maturation, particularly that of oligodendrocytes. HDAC11 deacetylation of histone H3 lysines 9 and 14 in the myelin basic protein and proteolipid protein genes stimulates their expression in oligodendrocytes, a notable example in which histone deacetylation, frequently associated with gene silencing, may in some cases have the opposite effect. HDAC11 negatively regulates IL-10 expression in antigen presenting cells (APCs), thus influencing whether APCs induce T cell activation or tolerance. Elevated HDAC11 expression is seen in a number of cancer cell lines. In myeloid leukemia lines, several HDAC inhibitors strongly induce HDAC11 expression, although the induction is more rapid with some inhibitors (TSA, SAHA) than others (butyrate, valproate). Such effects may be important to consider in the development and clinical application of HDAC inhibitors as cancer therapeutics. |
| Applications: | Useful for studies of enzyme kinetics, modulator activity, drug discovery. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | ~39 kDa |
| Purity: | Partially purified by single-step affinity chromatography and gel filtration. |
| Species: | Human |
| Formulation: | 50mM TRIS, pH 8.0, containing 138mM NaCl and 10% glycerol. |
| Accession#: | Q96DB2 |
| Alternative Names: | Histone deacetylase 11 |
| Tag: | His |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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