| Cat.No.: | PE-3824 |
| Product Name: | HDAC10 (human), (recombinant) (His-tag) |
| Description: | HDAC10 from human cDNA, transcript variant 1 (identical to GenBank accession NM_032019) is fused at the C-terminus to a His-tag. Produced in a baculovirus expression system. |
| Background: | HDAC10 is ubiquitously expressed in human tissues and many cell lines. Its domain structure resembles that of its closest homolog and fellow class IIb HDAC, HDAC6, but rather than two active deacetylase domains, it has one active domain (N-terminal) and a partially duplicated, inactive, C-terminal domain. Also like HDAC6, HDAC10 is resistant to inhibition by trapoxin B, sodium butyrate and valproic acid. Inhibition of one or both of the class IIb HDACs may be a desirable goal for cancer therapy. Inhibition or siRNA knockdown of both HDAC10 and HDAC6 causes depletion of the VEGFR1 and VEGFR2 proteins, suggesting a strategy for blocking angiogenesis via HDAC6/HDAC10 inhibition. An HDAC10 promoter polymorphism that increases transcription is associated with increased occurence of hepatocellular carcinoma in individuals with chronic hepatitis B infections. |
| Applications: | Useful for studies of enzyme kinetics, modulator activity, drug discovery. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | ~71 kDa |
| Purity: | Partially purified by single-step affinity chromatography and gel filtration. |
| Species: | Human |
| Formulation: | 50mM TRIS, pH 8.0, containing 138mM NaCl and 10% glycerol. |
| Accession#: | Q969S8 |
| Alternative Names: | Histone deacetylase 10 |
| Tag: | His |
| Expression System: | Sf9 Insect Cells |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0006 | Recombinant Human HDAC1 293 Cell Lysate | Inquiry |
| EL-0007 | Recombinant Human HDAC2 293 Cell Lysate | Inquiry |
| EL-0008 | Recombinant Human HDAC3 Cell Lysate | Inquiry |
| EL-0009 | Recombinant Human HDAC4 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0007 | Tubacin | Inquiry |
| Related Gene / Proteins | |||
| HDAC | HDAC1 | HDAC10 | HDAC11 |
| HDAC2 | HDAC3 | hdac4 | hdac5 |
| HDAC6 | hdac7 | HDAC8 | hdac9 |
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