| Cat.No.: | PE-3775 |
| Product Name: | BPTF bromodomain (2796-2907 aa) (GST-tagged), Human recombinant |
| Background: | The acetylation of histone lysine residues plays a crucial role in the epigenetic regulation of gene transcription. A bromodomain is a protein domain that recognizes acetylated lysine residues such as those on the N-terminal tails of histones. This recognition is often a prerequisite for protein-histone association and chromatin remodeling. These domains function in the linking of protein complexes to acetylated nucleosomes, thereby controlling chromatin structure and gene expression. Thus, bromodomains serve as “readers” of histone acetylation marks regulating the transcription of target promoters. BPTF is the largest component of the NURF chromatin remodeling complex. It includes adjacent PHD and bromodomains which recognize trimethylation of H3K4 or acetylation of lysines in histone 4, respectively. BPTF is an essential regulator of gene expression in early mouse embryos, and its knock-out is embryonic lethal. Duplication of the BPTF gene has been suggested to increase proliferation of cultured cancer cells, and aberrant BPTF copy numbers were found in 42% of the “NCI-60” panel of 60 human cancer cell lines. This protein product contains the bromodomain of BPTF. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Molecular Weight: | 40.1 kDa (2796-2907 aa + NT GST Tag) |
| Purity: | Purity by SDS-PAGE ≥80% |
| Formulation: | 50 mM Tris, pH 7.5, containing 500 mM sodium chloride, 5 mM β-mercaptoethanol and 5% glycerol. |
| Accession#: | Q12830 |
| Alternative Names: | Bromodomain PHD Finger Transcription Factor |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0035 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| CL-0484 | Human BPTF Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0544 | BPTF/FALZ TR-FRET Assay Kit | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1698 | FALZ (BPTF), GST-tag | Inquiry |
| PE-1701 | FALZ (BPTF), His-tag | Inquiry |
| Related Gene / Proteins | |||
| BPTF | |||
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
