| Cat.No.: | NUC-0148 |
| Product Name: | Human Native Nucleosome |
| Description: | Human native nucleosomes purified from HeLa cells, digested with micrococcal nuclease. |
| Background: | The nucleosome is the smallest part of the chromosome. It consists of two core histones of each class H2A, H2B, H3 and H4which assemble and are wrapped around 146 base pairs of DNA. Histones are the main constituents of the protein part ofchromosomes of eukaryotic cells. They pack the DNA into tight masses of chromatin. Histones are rich in the amino acidsarginine and lysine and have been greatly conserved during evolution. Histone tails undergo numerous post-translationalmodifications, which either directly or indirectly alter chromatin structure to facilitate transcriptional activation or repression orother nuclear processes. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Source: | HeLa cells |
| Appearance: | Liquid |
| Purity: | Purified using glycerol gradientand ion exchange chromatography, >98% purity as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | PBS containing 0.5 mM PMSF and 50%glycerol. |
| Concentrations: | 0.2 µg/µl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Nucleosomes | ||
| NUC-0001 | Recombinant Nucleosome | Inquiry |
| NUC-0002 | Native Nucleosome (HeLa-derived) | Inquiry |
| NUC-0003 | Native Nucleosome (HEK293-derived) | Inquiry |
| NUC-0004 | Recombinant Nucleosome | Inquiry |
| NUC-0005 | Nucleosomes (Chicken Oligo/Poly H5 Enriched) | Inquiry |
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