| Cat.No.: | PE-3746 |
| Product Name: | TDG recombinant protein |
| Description: | Active full length recombinant mouse N-terminal His tagged TDG (Thymine-DNA Glycosylase) protein, producedin SF9 insect cells |
| Background: | TDG (UniProt/Swiss-Prot entry Q13569) belongs to the TDG/mug DNA glycosylase family. It removes thymine moieties from G/Tmismatches by hydrolyzing the carbon-nitrogen bond between the sugar-phosphate backbone of DNA and the mispaired thymine.It is also able to remove thymine from C/T and T/T mispairings, although with lower activity. Furrther, TDG plays a key role inactive DNA demethylation as it binds to 5-formylcytosine (5fC) and 5-carboxylcytosine (5caC), but not 5-hydroxymethylcytosine(5hmC), and mediates their excision through base-excision repair (BER) to install an unmethylated cytosine. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | Purified using FPLC, >95% purity as determined by SDS-PAGE. |
| Species: | Mouse |
| Formulation: | 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 MNaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT. |
| Alternative Names: | HTDG |
| Tag: | His |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.5 µg/µl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Antibodies | ||
| EAb-0016 | TDRD4 Polyclonal Antibody | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0049 | Recombinant Human TDRD3 Cell Lysate | Inquiry |
| ◆ Cell Lines | ||
| CL-0285 | Human TDG Knockout Cell Line 2bp insertion | Inquiry |
| CL-0286 | Human TDGF1 Knockout Cell Line | Inquiry |
| CL-0431 | Human TDP1 Knockout Cell Line 13bp deletion | Inquiry |
| Related Gene / Proteins | |||
| TDF | TDG | TDGF1 | TDP1 |
| TDRD12 | TDRD3 | TDRD4 | TDRD4 |
| TDT | |||
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