| Cat.No.: | PE-3743 |
| Product Name: | TRIM33 recombinant protein |
| Description: | Full length recombinant human N-terminal Flag tagged TRIM33 (Tripartite Motif Containing 33) protein, producedin SF9 insect cells. |
| Background: | TRIM33 (UniProt/Swiss-Prot entry Q9UPN9) is a member of the tripartite motif (TRIM) family. The TRIM motif includes threezinc-binding domains - a RING, a B-box type 1 and a B-box type 2 - and a coiled-coil region. TRIM33 is an E3 ubiquitin-proteinligase, which promotes SMAD4 ubiquitination, nuclear exclusion and degradation via the ubiquitin proteasome pathway. It mayact as a transcriptional corepressor and inhibits the transcriptional response to the TGF-beta/BMP signaling cascade. However,molecules that interact with this protein have not yet been identified..TRIM33 also plays a role in the control of cell proliferation.Its association with SMAD2 and SMAD3 stimulates erythroid differentiation of hematopoietic stem/progenitor. Defects in TRIM24cause thyroid papillary carcinoma. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Purity: | Purified using FPLC, >95% purity as determined by SDS-PAGE. |
| Species: | Human |
| Formulation: | 20 mM Tris-Cl pH 7.6, 1 mM EDTA, 0.15 MNaCl, 10% glycerol, 0.5 mM PMSF and 1 mM DTT. |
| Alternative Names: | TIF1G, TIF1gamma, TF1G, RFG7, ECTO, PTC7 |
| Tag: | FLAG |
| Expression System: | Sf9 Insect Cells |
| Concentrations: | 0.5 µg/µl |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| BSM-0021 | PF-03814735 | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0107 | Recombinant Human TRIM68 293 Cell Lysate | Inquiry |
| EL-0109 | Recombinant Human TRIP4 Lysate | Inquiry |
| EL-0115 | Recombinant Human TRIM24 293 Cell Lysate | Inquiry |
| Related Gene / Proteins | |||
| TRA2A | TRAF4 | TRAF5 | TRAF6 |
| TRAK2 | TRBP | TRDMT1 | TREX1 |
| TRF2 | TRIM11 | TRIM13 | TRIM16 |
| TRIM17 | TRIM2 | TRIM21 | trim24 |
| TRIM26 | TRIM28 | TRIM3 | TRIM33 More > |
| TRIM34 | TRIM35 | TRIM36 | TRIM37 |
| TRIM38 | TRIM39 | TRIM4 | TRIM5 |
| TRIM55 | TRIM6 | TRIM63 | TRIM66 |
| TRIM68 | TRIM8 | TRIM9 | TRIML1 |
| TRIP4 | Tristetraprolin | TRIT1 | TrkA |
| TRMT2A | TRMT44 | TRMT5 | TRMT6 |
| TROVE2 | TRUB2 | TRX1 | TRβ1 |
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