| Cat.No.: | PE-3700 |
| Product Name: | Recombinant NSD2 (E1099K) protein |
| Product Overview: | Recombinant human NSD2 (E1099K) was expressed in a baculovirus expression system as the full length protein (accession number NP_579877.1) with a point mutation (Glu1099Lys) and an N-terminal FLAG-Tag. The molecular weight of the protein is 154 kDa. The purity of NSD2 (E1099K) protein is >75% by SDS-PAGE. |
| Background: | NSD2 (nuclear receptor binding SET domain protein 1; also known as WHSC1; MMSET; TRX5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The NSD2 gene is deleted in Wolf- Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to NSD2 gene being aberrantly placed under the control of the IgH intronic µ enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in NSD2 expression in a myeloma cell line suppressed its growth, suggesting a role for NSD2 in maintaining the transformed state.NSD2 p.Glu1099Lys (p.E1099K) variant was identified in nontranslocated acute lymphoblastic leukemia (ALL) cell lines. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES pH 7.5, 500 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0113 | Human NSD1 Knockout Cell Line 4bp deletion | Inquiry |
| ◆ Research Kits | ||
| EKIT-0287 | NSD1 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0494 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0498 | NSD3 Chemiluminescent Assay Kit | Inquiry |
| EKIT-0502 | NSD2 Chemiluminescent Assay Kit | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | |
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