| Cat.No.: | PE-3699 |
| Product Name: | Recombinant NSD2 (MMSET)-SET protein |
| Product Overview: | Recombinant NSD2 (MMSET)-SET peptide that includes amino acids 942-1240 that contains the SET domain sequence of the human NSD2 (MMSET)-SET protein (accession number NP_579877.1) was expressed in E. coli cells and contains an N-terminal GST-Tag with an observed molecular weight of 60 kDa. The recombinant protein is >90% pure by SDS-PAGE. |
| Background: | NSD2 (MMSET)-SET (Multiple Myeloma SET domain-containing protein, WHSC1/Wolf-Hirschhorn Syndrome Candidate 1, Nuclear Receptor binding SET domain protein 2, TRX5, Trithorax 5) is a SET domain-containing histone methyltransferase specific for lysine 36 of histone H3. The NSD2 (MMSET)-SET gene is deleted in Wolf-Hirschhorn syndrome, a disorder characterized by developmental defects and mental retardation. In 15% of patients with Multiple Myeloma (MM), a chromosomal translocation leads to NSD2 (MMSET)-SET gene being aberrantly placed under the control of the IgH intronic µ enhancer and expressed at very high levels. This event is apparently a key component in cellular transformation leading to MM. Reduction in NSD2 (MMSET)-SET expression in a myeloma cell line suppressed its growth, suggesting a role for NSD2 (MMSET)-SET in maintaining the transformed state. NSD2 (MMSET)-SET includes the SET domain of NSD2 (MMSET)-SET. The SET domain is a 130 to 140 amino acid, evolutionary conserved motif that was initially characterized in the Drosophila proteins Su(var)3-9, EZH2 and TrxG and plays a crucial role in substrate recognition and enzymatic activity. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris pH 8.0, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100. |
| Tag: | GST |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| nsd1 | NSD2 | NSD3 | NSMCE2 |
| NSUN1 | NSUN2 | NSUN3 | NSUN4 |
| NSUN5 | NSUN6 | NSUN7 | SENP3 |
| SENP8 | SET | SET1 | SET2 |
| SET7 | SET8 | SET9 | SETBP1 More > |
| SETD1A | SETD1B | SETD2 | SETD3 |
| SETD5 | SETD6 | SETD7 | SETD8 |
| SETD9 | SetDB1 | SETDB2 | SETMAR |
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