| Cat.No.: | PE-3676 |
| Product Name: | Recombinant SETMAR protein |
| Product Overview: | Recombinant SETMAR (accession number NP_006506.3) was expressed in Sf9 cells and contains an N-terminal FLAG-Tag with an observed molecular weight of 79 kDa. |
| Background: | SETMAR (SET Domain and mariner transposase fusion gene) is a ubiquitously expressed nuclear fusion protein that contains an N-terminal SET domain with histone methyltransferase activity and a C-terminal mariner (MAR) transposase domain that recognizes and binds DNA. The gene exists as a fusion gene only in anthropoid primates; other organisms lack mariner transposase domain. SETMAR binds DNA and functions in DNA repair activities including non-homologous end joining and double strand break repair. The mariner transposase domain recognizes and binds the 19-mer core of the 5’-TIR (terminal inverted repeats) of the Hsmar1 element. The SET domain specifically methylates lysines 4 and 36 of histone H3 which are epigenetic marks associated with transcriptional activation. SETMAR demonstrates in vivo end joining activity and may mediate genomic integration of foreign DNA. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES pH 7.5, 300 mM NaCl, 5% glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0030 | SETD8 Polyclonal Antibody | Inquiry |
| EAb-0031 | SETDB1 Polyclonal Antibody | Inquiry |
| EAb-0032 | Setd1a Polyclonal Antibody | Inquiry |
| EAb-0033 | Setd1b Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| SENP3 | SENP8 | SET | SET1 |
| SET2 | SET7 | SET8 | SET9 |
| SETBP1 | SETD1A | SETD1B | SETD2 |
| SETD3 | SETD5 | SETD6 | SETD7 |
| SETD8 | SETD9 | SetDB1 | SETDB2 More > |
| SETMAR | |||
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