| Cat.No.: | PE-3635 |
| Product Name: | Recombinant CECR2 (425-538) protein |
| Product Overview: | The peptide corresponding to amino acids 425 - 538 that contains the bromodomain sequences of CECR2 (accession number NM_031413.3) was expressed in E. coli and contains an N-terminal His-Tag and C-terminal FLAG-Tag with an observed molecular weight of 19.7 kDa. It shows binding specificity for acetylated H3K9, H3K14, H3K9/K14 and H3K9/S10/K14. The recombinant protein is >90% pure by SDS-PAGE. |
| Background: | CECR2 protein is the bromodomain-containing subunit of the CERF (CECR2-containing-remodeling factor) complex. Bromodomains recognize acetylated histone lysine residues and function as ‘readers’ of these epigenetic histone marks to regulate chromatin structure and gene expression by linking associated proteins to the recognized acetylated nucleosomal targets. The CERF complex functions to facilitate the perturbation of chromatin structure in an ATP-dependent manner. In addition to its chromatin remodeling function, CECR2 interaction with LRPPRC may be involved in the integration of the cytoskeletal network with processes such as vesicular trafficking, nucleocytosolic shuttling, transcription, chromosome remodeling and cytokinesis. |
| Applications: | Suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 8.0, 500 mM NaCl, 0.04% Triton X-100, 20% glycerol, 1mM TCEP. |
| Tag: | His & FLAG |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0054 | Human CECR2 Knockout Cell Line 13bp deletion | Inquiry |
| ◆ Synthetic Peptides | ||
| SP-0191 | Human CENPA peptide | Inquiry |
| ◆ Extracts & Lysates | ||
| EL-0219 | Recombinant Human CENPA 293 Cell Lysate | Inquiry |
| EL-0220 | Recombinant Human CENPA 293 Cell Lysate | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0340 | NVS-CECR2-1 | Inquiry |
| Related Gene / Proteins | |||
| CEACAM1 | CECR1 | CECR2 | CELF-5 |
| CELF-6 | CENH3 | CENPA | CENPB |
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