| Cat.No.: | PE-3628 |
| Product Name: | Recombinant PBRM1 (464-605) protein |
| Product Overview: | The peptide corresponding to amino acids 464 - 605 that contains the bromodomain sequences of PBRM1 (accession number NM_018165.4) was expressed in E. coli and contains an N-terminal His-Tag and C-terminal FLAG-Tag with an observed molecular weight of 22.5 kDa. It shows binding specificity for acetylated H3K23. |
| Background: | Polybromo 1 (PBRM1) protein, also known as BRG1-associated factor 180 (BAF180) is the chromatin targeting subunit of the SWI/SNF-B (PBAF) chromatin remodeling complex that is involved in transcriptional activation and repression of select genes. PBRM1 targets chromatin via its six bromodomains that recognize and bind acetylated histone lysine residues. Bromodomains function as ‘readers’ of these epigenetic histone marks and regulate chromatin structure and gene expression by linking associated proteins to the acetylated nucleosomal targets. PBRM1 also acts as an inhibitor of cell proliferation and demonstrates tumor suppressing properties in relation to breast, liver and lung cancers. |
| Applications: | Suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM Tris-HCl pH 8.0, 300 mM NaCl and 10% glycerol. |
| Tag: | His & FLAG |
| Expression System: | E. coli |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0114 | Human PBRM1 Knockout Cell Line 8bp deletion | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1119 | Recombinant Zebrafish PBRM1L | Inquiry |
| PE-1695 | PB1 (BD4), His-tag | Inquiry |
| PE-1717 | PB1 (BD6), His-tag | Inquiry |
| ◆ Antibodies | ||
| EAb-1869 | PBX2 Monoclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| PB1 | PBI | PBRM1 | PBRM1L |
| PBX | PBX1b | PBX2 | |
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