| Cat.No.: | PE-3494 |
| Product Name: | Recombinant JMJD2C / KDM4C protein |
| Product Overview: | Recombinant JMJD2C / KDM4C (accession number NP_055876.2) was expressed in Sf9 cells and contains an N-terminal 6xHis-Tag and a FLAG-Tag with a calculated molecular weight of 124.1 kDa. The recombinant protein is >95% pure by SDS-PAGE. |
| Background: | KDM4C (lysine (K)-specific demethylase 4C), also known as JMJD2C (Jumonji Domain Containing 2C) is a nuclear protein that functions as a histone demethylase that preferentially demethylates di- and trimethylated lysine 9 (K9me3) and lysine 36 (K36me3) residues of histone H3, converting these trimethylated histone residues to mono- or dimethylated form. JMJD2C / KDM4C has no activity for monomethylated H3K9 and H3K36. Chromosomal aberrations and overexpression of KDM4C are associated with esophageal squamous cell carcinoma. KDM4C regulates colonosphere formation in colorectal cancers by mediating the crosstalk between Wnt and Notch signaling pathways. |
| Applications: | Suitable for use in the study of enzyme kinetics, inhibitor screening, and selectivity profiling |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES pH 7.5, 300 mM NaCl, 5% Glycerol, 0.04% Triton X-100, 0.2 mM TCEP. |
| Tag: | His & FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Cell Lines | ||
| CL-0015 | Human KDM5B Knockout Cell Line 14bp deletion | Inquiry |
| ◆ Bioactive Small Molecules | ||
| BSM-0027 | UNC0321 (trifluoroacetate salt) | Inquiry |
| ◆ Antibodies | ||
| EAb-0071 | KDM1B Polyclonal Antibody | Inquiry |
| EAb-0072 | JMJD6 Polyclonal Antibody | Inquiry |
| EAb-0074 | JMJD2c Polyclonal Antibody | Inquiry |
| Related Gene / Proteins | |||
| JMJD | JMJD1A | JMJD1B | JMJD1C |
| JMJD2 | JMJD2A | JMJD2B | JMJD2C |
| JMJD2D | JMJD2E | JMJD2F | JMJD3 |
| JMJD4 | JMJD5 | JMJD6 | KDM1 |
| KDM1A | KDM1B | KDM2 | KDM2A More > |
| KDM2B | KDM3A | KDM3B | KDM4 |
| KDM4A | KDM4B | KDM4C | KDM4D |
| KDM4E | KDM5 | KDM5A | KDM5B |
| KDM5C | KDM5D | KDM6A | KDM6B |
| KDM6C | KDM7 | KDM7A | KDM7B |
| KDM8 | |||
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