| Cat.No.: | PE-3473 |
| Product Name: | Recombinant c-Fos protein |
| Product Overview: | Recombinant c-Fos was expressed from full length (accession number NM 003131) with an N-terminal His-Tag in a baculovirus system and purified by an affinity column in combination with FPLC chromatography. The purified recombinant protein is greater than 90% homogeneous and contains no detectable protease, DNase and RNase activity. |
| Background: | c-Fos is one of the proteins that form the heteromeric AP-1 transcription factor complex. AP-1 proteins play a role in the expression of many genes involved in the regulation of cellular processes such as differentiation, proliferation and apoptosis. The transcription factor AP-1 is composed of a mixture of heterodimeric protein complexes derived from the Fos and Jun families, including c-Fos, FosB, Fra-1, c-Jun, JunB and JunD. c-Fos is a nuclear phosphoprotein that forms a tight but non-covalently linked complex with the Jun/AP-1 transcription factor. In the heterodimer, Fos and Jun/AP-1 basic regions each seem to interact with symmetrical DNA half sites. Upon TGF-β activation, c-Fos forms a multimeric SMAD3/SMAD4/Jun/Fos complex at the AP-1/SMAD-binding site to regulate TGF-β-mediated signaling. c-Fos has a critical function in regulating bone morphogenesis. |
| Applications: | Suitable for DNA and protein-protein interaction assays. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | Dilution Buffer AM1 (20 mM Tris-Cl (pH 8), 20% glycerol, 100 mM KCl, 1 mM DTT and 0.2 mM EDTA). |
| Tag: | His |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Bioactive Small Molecules | ||
| BSM-0018 | Danusertib (PHA-739358) | Inquiry |
| ◆ Antibodies | ||
| EAb-1913 | c-Myc Polyclonal Antibody (65 kDa form) | Inquiry |
| EAb-1914 | c-Myc Monoclonal Antibody | Inquiry |
| EAb-1941 | c-Jun Polyclonal Antibody | Inquiry |
| ◆ Proteins & Enzymes | ||
| PE-1983 | C-jun Protein | Inquiry |
| Related Gene / Proteins | |||
| c-Fos | c-Jun | c-MET | c-Myc |
| c-RET | |||
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