| Cat.No.: | PE-3434 |
| Product Name: | Recombinant METTL21B protein |
| Product Overview: | Recombinant METTL21B protein was expressed in a baculovirus expression system as the full length human protein (accession number NP_056248.2) with an N-terminal FLAG tag. The molecular weight of the protein is 26 kDa. |
| Background: | METTL21B (Methyltransferase-Like Protein 21B), also known as EEF1AKMT3 ((Eukaryotic Translation Elongation Factor 1 Alpha Lysine Methyltransferase 3), is a member of the Family 16 group of methyltransferases. EEF1A is a translation factor which delivers amino-acyl tRNA to the ribosome during translational elongation. In human, EEF1A shows high levels of methylation and has at least six known methylation sites, namely methylation at its N terminus and at lysines 36, 55, 79, 165, and 318. Of these, METTL21B selectively catalyzes the trimethylation of EEF1A at Lys 165. In addition, EEF1AKMT4, METTL13, N6AMT2 (EEF1AKMT1) and METTL10 (EEF1AKMT2) are the methyltransferases for lysines 36, 55, 79 and 318, respectively. EEF1A methylation by EEF1AKMT3 is dynamic as well as inducible by stress conditions, such as ER-stress, and plays a regulatory role on mRNA translation. |
| Applications: | Suitable for use in binding assays, inhibitor screening, and selectivity profiling. |
| Storage: | Store at 4℃ if entire vial will be used within 2-4 weeks. Store at -20℃ or -80℃ for longer periods of time. Avoid multiple freeze-thaw cycles. |
| Appearance: | Liquid |
| Species: | Human |
| Formulation: | 25 mM HEPES-NaOH |
| Tag: | FLAG |
| Expression System: | Baculovirus |
| Warning: | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Product Types | ||
| ◆ Extracts & Lysates | ||
| EL-0043 | Recombinant Human MECP2 293 Cell Lysate | Inquiry |
| EL-0111 | Recombinant Human MEF2B Cell Lysate | Inquiry |
| ◆ Antibodies | ||
| EAb-0067 | MeCP2 Polyclonal Antibody | Inquiry |
| ◆ Cell Lines | ||
| CL-0109 | Human MECP2 Knockout Cell Line 1bp insertion | Inquiry |
| CL-0110 | Human MEN1 Knockout Cell Line 1bp insertion | Inquiry |
USA
Enter your email here to subscribe.
Follow us on
Easy access to products and services you need from our library via powerful searching tools
